Donepezil for The Preparation of Alzheimer′s Disease

• Overview
• FAQ
• FAQ

Overview

Basic Info.

Model NO.	Customized on demand
Grade Standard	Medicine Grade
Type	Chemical Reagent
State	Solid
Volatile	Not Volatile
Transport Package	According to Customer Requirements
Specification	1kg/piece
Trademark	none
Origin	China

Product Description

Q: When can I get the price?
A: We usually quote within 24 hours after we get your inquiry.
If you are very urgent to get the price, please tell us so that we will regard your inquiry priority.

Q: How can I get a sample to check your quality?
A: After price confirmation, we are happy for sending samples in 2 days to you once you need.

Q: What about the lead time for mass production?
A: Honestly, it depends on the order quantity and the season you place the order. Usually it takes 45days.

Q: What is your terms?
A: We accept EXW, FOB, CFR, CIF, DDU, DDP, etc. You can choose the one which is the most convenient or cost effective for you.

Q: When can I get the price?
A: We usually quote within 24 hours after we get your inquiry.
If you are very urgent to get the price, please tell us so that we will regard your inquiry priority.

Q: How can I get a sample to check your quality?
A: After price confirmation, we are happy for sending samples in 2 days to you once you need.

Q: What about the lead time for mass production?
A: Honestly, it depends on the order quantity and the season you place the order. Usually it takes 45days.

Q: What is your terms?
A: We accept EXW, FOB, CFR, CIF, DDU, DDP, etc. You can choose the one which is the most convenient or cost effective for you.

Donepezil has a reversible and non-competitive inhibitory effect on AChE. It is 500-1000-fold more selective for AChE than for BuChE. Short- and long-term drug exposure to human SH-SY5Y neuroblastoma cells induces a concentration-dependent inhibition of cell proliferation independent of muscarinic or nicotinic receptor blockade and apoptosis. Donepezil reduces the number of cells in the S-G2/M phase of the cell cycle, increases the number in the G0/G1 phase, and reduces the expression of two cyclins in the G1/S and G2/M transitions: cyclinE and cyclinB. At the same time, it also increased the expression of the cell cycle repressor p21. In addition, donepezil increases action potential-dependent dopamine release and modulates nicotinic receptors in substantia nigra dopaminergic neurons. In vivo studies Donepezil is slowly absorbed from the gastrointestinal tract in vivo, with a terminal half-life of 50-70 hours in young volunteers, and a half-life of more than 100 hours in the elderly. After extensive hepatic metabolism, the parent compound is 93% bound to plasma proteins. Donepezil is metabolized in the liver by the cytochrome P450 system (CYP1A2-, CYP2D6-, CYP3A4-related enzymes). In animals, donepezil was unchanged in the brain and no metabolites were found in neural tissue. In plasma, urine and bile, most donepezil metabolites are O-glucuronides. After oral ingestion, peak plasma concentrations are reached within 3-5 hours, and its absorption is not affected by food. Donepezil has linear pharmacokinetics in the concentration range of 1-10 mg/day. 96% of circulating donepezil is protein bound. Uses Donepezil hydrochloride monohydrate is a centrally reversible acetylcholinesterase inhibitor.
FAQ FAQ

NO.API		CAS NO.	Quality Standard	DMF
1,Antibiotics
	Ceftizoxime Sodium	68401-82-1	CP,USP,JP
2	Cefoxitin Sodium	33564-30-6	USP,EP,BP,CP
3	Cefotiam Hydrochloride	66309-69-1	JP,USP.IH
4	Cefazedone Sodium	63521-15-3	KP,YBH
5	Cefoperazone Sodium	62893-20-3	CP,USP,EP,BP,JP
6	Sulbactam Sodium	69388-84-7	EP,USP,BP,KP,CP
7	Cefoperazone Sodium andSulbactam Sodium (1:1) 1:1		.H
8	Cefuroxime Sodium	56238-63-2	EP,USP,JP,BP,CP,IP,KP
9	Ceftezole Sodium	41136-22-5	CP	√
10	Cefamandole Nafate	42540-40-9	USP,EP,BP,CP
11	Cefepime Hydrochloride with Arginine()	107648-80-6	USP,CP,IP	√
12	Biapenem	120410-24-4	I.H
13	Aztreonam()	78110-38-0	CP,IP	√
II,Cardiovascular and Cerebral System APIs
1	Tirofiban Hydrochloride	150915-40-5	I.H	√
2	Ticagrelor	274693-27-5	l.H	Preparing
3	Rivaroxaban	366789-02-8	I.H	√
4	Edaravone	89-25-8	JP,CP
5	Donepezil Hydrochloride	120011-70-3	USP,EP,JP,CP	Preparing
6	Carbazochrome Sodium Sulfonate	51460-26-5	JP,I.H
	Vildagliptin	274901-16-5	I.H
II,Others
1	Omeprazole Enteric-coated Pellets ()	73590-58-6	I.H
2	Loxoprofen Sodium	80382-23-6	JP,KP,I.H	√
3	Parecoxib Sodium	198470-85-8	I.H	√
4	Ambroxol Hydrochoride	23828-92-4	EP,BP.CP	√
5\			USP,EP,I.H
6	Gemcitabine Hydrochloride	122111-03-9	USP,EP,BP,CP	√
IV,Intermediate
1	Tirofiban Hydrochloride Intermediate II	149490-61-9
	Tirofiban Hydrochloride Intermediatell	144494-65-5
	Tirofiban Hydrochloride IntermediatellII	150915-40-5
2	Rivaroxaban Intermediate I1	446292-07-5
	Rivaroxaban Intermediate I	446292-08-6
	Rivaroxaban IntermediateIII	898543-06-1
3	Vildagliptin Intermediate II	214398-99-9
	Vildagliptin Intermediatell	207557-35-5
4	Loxoprofen Acid	68767-14-6
	TadalafilIntermediate II	14907-27-8
6	Cefazolin	25953-19-9
	Cefoperazone	62893-19-0
8	Cefazedone	56187-47-4
	7-TDA	30246-33-4
9	Cefoxitin	35607-66-0